Calorie Deficits Explained: the mTOR & Hormone Crosstalk
Science says eating just one meal per day can improve your health. Learn more at https://highintensityhealth.com/OMAD ----- We've grossly oversimplified what it means to be in a "calorie deficit or surplus". Associated video with Thomas DeLauer: https://youtu.be/mKEn86kbC3w Join us at FitCon next week: https://fitcon.com/summit/#tickets Coupon code: HIH In this video, we discuss the biology about how our cells rely upon messages from hormones and kinases (mTOR and AMPK) to detect energy status and activate down-stream cellular processes accordingly. Why care about these cellular switches? Well they're ultimately responsible for how our organs respond to our energy status and demands. BUT...these very kinases also respond to hormones and various non-nutritive factors (cellular stress etc...). So energy balance matters, obviously, but there's more to the story Key Science Review Mentioned: Laplante, M., & Sabatini, D. M. (2012). mTOR Signaling in Growth Control and Disease. Cell, 149(2), 274–293. http://doi.org/10.1016/j.cell.2012.03.017 ➢ New MYOXCIENCE Formulas: Keto + MCT MicroDose: http://bit.ly/2ErlGz8 Autophagy Enhancer Bundle: http://bit.ly/2SLvJJG ---------------------------------- TOOLS & VIDEO GEAR----------------------------------------- Best Omega-3 Fish Oil: https://amzn.to/2xs08CC Blue Blockers: http://bit.ly/2En0oUy Best Vlog & FB Live Stabilizer: https://amzn.to/2wcoJXZ Nice HD Camera Canon 6D Mark II https://amzn.to/2JyxrG5 Interview Cam C100 ii: https://amzn.to/2EC5NE8 Best Lens Ever: https://amzn.to/2IJ9WZC Vlog lens: Canon EF-S 17-55mm f/2.8 IS: https://amzn.to/2IGlfSo Dope Lens - Canon 85mm f/1.4L IS: https://amzn.to/2IFRG3h Good Audio: Rode VMPRPLUS Videomic Pro: https://amzn.to/2v9W9cm -----------------------------------------Lets Connect-------------------------------------- ➢ iTunes Podcast: https://itunes.apple.com/us/podcast/1... ➢ Instagram https://www.instagram.com/metabolic_mike ➢ Facebook https://www.facebook.com/MikeMutzelMS -------------------------------------- Key Timestamps---------------------------------- 00:40: Hormones and energy balance are interconnected 01:30 mTOR as a primary energy sensor 02:51 How hormones influence & regulate energy switches 03:13 The anabolic vs catabolic balance (energy surpluses vs deficits) 03:52 How mTOR gets activated 04:51 Catabolic states, exercise and AMPK 05:40 Insulin, glucagon and malonyl-CoA: the triad that regulates fat synthesis and oxidation 07:10 The big picture of energy balance in the context of lifestyle change
Science says eating just one meal per day can improve your health. Learn more at https://highintensityhealth.com/OMAD ----- We've grossly oversimplified what it means to be in a "calorie deficit or surplus". Associated video with Thomas DeLauer: https://youtu.be/mKEn86kbC3w Join us at FitCon next week: https://fitcon.com/summit/#tickets Coupon code: HIH In this video, we discuss the biology about how our cells rely upon messages from hormones and kinases (mTOR and AMPK) to detect energy status and activate down-stream cellular processes accordingly. Why care about these cellular switches? Well they're ultimately responsible for how our organs respond to our energy status and demands. BUT...these very kinases also respond to hormones and various non-nutritive factors (cellular stress etc...). So energy balance matters, obviously, but there's more to the story Key Science Review Mentioned: Laplante, M., & Sabatini, D. M. (2012). mTOR Signaling in Growth Control and Disease. Cell, 149(2), 274–293. http://doi.org/10.1016/j.cell.2012.03.017 ➢ New MYOXCIENCE Formulas: Keto + MCT MicroDose: http://bit.ly/2ErlGz8 Autophagy Enhancer Bundle: http://bit.ly/2SLvJJG ---------------------------------- TOOLS & VIDEO GEAR----------------------------------------- Best Omega-3 Fish Oil: https://amzn.to/2xs08CC Blue Blockers: http://bit.ly/2En0oUy Best Vlog & FB Live Stabilizer: https://amzn.to/2wcoJXZ Nice HD Camera Canon 6D Mark II https://amzn.to/2JyxrG5 Interview Cam C100 ii: https://amzn.to/2EC5NE8 Best Lens Ever: https://amzn.to/2IJ9WZC Vlog lens: Canon EF-S 17-55mm f/2.8 IS: https://amzn.to/2IGlfSo Dope Lens - Canon 85mm f/1.4L IS: https://amzn.to/2IFRG3h Good Audio: Rode VMPRPLUS Videomic Pro: https://amzn.to/2v9W9cm -----------------------------------------Lets Connect-------------------------------------- ➢ iTunes Podcast: https://itunes.apple.com/us/podcast/1... ➢ Instagram https://www.instagram.com/metabolic_mike ➢ Facebook https://www.facebook.com/MikeMutzelMS -------------------------------------- Key Timestamps---------------------------------- 00:40: Hormones and energy balance are interconnected 01:30 mTOR as a primary energy sensor 02:51 How hormones influence & regulate energy switches 03:13 The anabolic vs catabolic balance (energy surpluses vs deficits) 03:52 How mTOR gets activated 04:51 Catabolic states, exercise and AMPK 05:40 Insulin, glucagon and malonyl-CoA: the triad that regulates fat synthesis and oxidation 07:10 The big picture of energy balance in the context of lifestyle change